Sir Thomas Clayton (c 1612 – 4 October 1693), known in his father's lifetime as Thomas Clayton the Younger, was an English physician and professor of medicine who sat in the House of Commons in 1660.
Clayton was the son of Thomas Clayton, MD of Oxford, the last Principal of Broadgates Hall, and the first Master of Pembroke College.
He enrolled there on 25 May 1627, aged fifteen, and graduated BA on 22 January 1629, MA on 17 October 1631.
He was Regius Professor of Medicine at Oxford from 1647 to 1665, succeeding his father.
[3] From 1661 to 1693, he was a warden at Merton College, Oxford.