In 2009, when he was 16 years old, Detry won the Dutch Junior Open, a competition for young golfers aged under 21.

[5] Following fellow golfer and good friend Thomas Pieters,[6] Detry studied Business Management at the University of Illinois from 2012 to 2016.

With this win, he equaled the record for lowest under-par finish ever on the Challenge Tour (29 under par, set in 2003 by Ivó Giner), and set a new record for the win by the widest margin ever on the Challenge Tour – 12 strokes ahead of the second-place finisher.

[11] In August 2020, Detry twice finished solo runner-up at tournaments on the European Tour, at the Hero Open in Birmingham, England[12] and at the Celtic Classic at the Celtic Manor Resort in Wales, both times beaten by Sam Horsfield,[13] and advanced to 75th on the Official World Golf Ranking.

In February 2025, Detry became the first Belgian to win on the PGA Tour when he won the WM Phoenix Open.