Thomas Egan (November 1, 1874 – April 20, 1919) was an American politician and organized crime figure involved in bootlegging and illegal gambling in St. Louis, Missouri.

The son of an Irish-American saloonkeeper, Egan was born and raised in Kerry Patch, then known as the riverfront Irish ghetto of St. Louis.

Acquitted of Gagel's murder, Egan was soon confronted by one of his top men, James "Kid" Wilson, whom he suspected was having an affair with his wife Nellie.

In one famous sentence, Egan boasted, "...we don't shoot unless we know who is present," sounding eerily like Bugsy Siegel saying forty years later, "We only kill each other."

Knowing that the up-and-coming Prohibition movement would become the law of the land, Tom Egan set up a liquor smuggling network as early as the mid-1910s.