Grey took some part in resisting the arbitrary actions of James II, and was arrested in July 1685.

After his release he took up arms on behalf of William of Orange in the Glorious Revolution, after whose accession to the throne he was made a Privy Counsellor (1694) and Lord Lieutenant of Devon (1696).

[1] Politically he was described as an "unrepentant Whig", who reaffirmed his belief in the Popish Plot by voting against the motion to reverse the attainder on William Howard, 1st Viscount Stafford.

In 1697 he became Chancellor of the Duchy of Lancaster, and in 1699 President of the Board of Trade, being dismissed from his office upon the accession of Anne in 1702.

[1] The arms of the head of the Grey family are blazoned Barry of six argent and azure in chief three torteaux gules.