Thomas Harrington Tuke FRCPE FRCP (13 June 1826 - 1888) was a British physician who specialised in psychiatry.

He ran and enlarged the private Manor House Asylum in Chiswick (founded by his father Edward Francis Tuke), published papers on general paralysis and related topics, and contributed to the development of lunacy legislation in Victorian England.

He was secretary of the Medico-Psychological Association and testified before select committees of the House of Commons on amendments to the lunacy laws.

Tuke was an experienced psychiatric witness and took part in the William Frederick Windham case (in which he took a position contrary to Dr Forbes Benignus Winslow), in the divorce action against Lady Mordaunt, and in the Bravo and George Victor Townley cases.

[1] Two of their sons Thomas Seymour and Charles Molesworth Tuke, both doctors, continued running the asylum and supervised its move to Chiswick House in 1893, where it remained until its closure in 1929.