Holme was a member of the Valiant Sixty, a group of early leaders and activists in the Religious Society of Friends, known as the Quakers.
Soon after his marriage, Holme enlisted in the British Army, which was then under the leadership of Oliver Cromwell, where he attained the rank of captain.
[1] Holme designed the plan of the city of Philadelphia and produced the first detailed map of Pennsylvania, titled A Mapp of Ye Improved Part of Pensilvania in America, Divided Into Countyes, Townships and Lotts...., published circa 1687.
[1] Holme held the office of Surveyor-General until his death at age 71 in the spring of 1695, in Dublin Township, Pennsylvania in the present-day Holmesburg section of Philadelphia.
In 1863, a memorial was erected at his burial site, in the form of a six-foot-tall marble obelisk, near where his home is believed to have been located, which is now part of Pennypack Park.