Sir Thomas Humphrey (c. 1554 – 4 February 1624) was an English politician.
He was a younger son of William Humphrey of Barton Segrave and Swepstone, Leicestershire and educated at Peterhouse, Cambridge.
He was a Member (MP) of the Parliament of England for Newcastle-under-Lyme in 1589.
He married twice: firstly Mary, the daughter of William Mering of Mering, Northamptonshire and secondly Suzanna, the daughter of George Pilkington of Barston, with whom he had 3 sons and 3 daughters.
This article about a 16th-century member of the parliament of England is a stub.