On August 27, 1973, the new Jefferson High School building was opened at its current location on West Cypress Street.

The courses have since changed names and have slowly moved on from focusing on international studies to being college preparatory leadership academies for students.

Thomas Jefferson High School offers the following College Preparatory Leadership Academies to magnet students who apply:[7] In 2010, the Dragons won the Class 3A State Championship.

DECA, FBLA, FCCLA, FPSA (Florida Public Service Association), Tri-M Music Honor Society, Mock Trial Team Junior Civitan, Key Club, SAC (student advisory council), SADD, Shanti.

Arriba, Ballroom Dancing, FCA, True Love Does Wait, Nubian Queens, Science Brain Bowl, YO, Model United Nations, Human Rights, Step, Male/Female Weightlifting, Hip-Hop, Crew, Best Buddies, Drama, Health Club.