In his junior season at Concord University, he was selected to the preseason Consensus Draft Services (CDS) First-team All-American team.
[5] On January 24, 2011, he was selected to the Don Hansen First-team All-American team while at Concord University.
[12] On December 3, 2012, Mayo signed with the Chicago Rush of the Arena Football League.
After two games of the regular season, Mayo was released to attend the 2015 NFL Veteran Combine.
Mayo was with the Winnipeg Blue Bombers of the Canadian Football League during the 2016 training camp.