[3] While Oxley has been conducting research in motor systems since 2003, he is said to have conceived the idea for the Stentrode™ in 2007 and he led the original team at the University of Melbourne that created the technology.

Oxley's team in Australia was the only non-US-based group funded by DARPA as part of the Reliable Neural-Interface Technology (RE-NET) program and led by Professor Jack Judy.

Dr. Oxley announced in a 2018 TEDxSydney Talk[4] that the company, Synchron, would initiate clinical trials of the Stentrode device with the goal of assisting paralyzed patients to regain independence.

The study showed the ability of two Australians with ALS to email, text, shop, and bank online using the Stentrode Device, and was conducted at Royal Melbourne Hospital.

Oxley and his colleagues at Mount Sinai reported an increased incidence of stroke identified in patients under 50 years of age with COVID-19, which was published in New England Journal of Medicine in April 2020.