The son of the Reverend John Pyle (died 1709), Rector of Stody, he was educated at Gresham's School, Holt, and at Gonville and Caius College, Cambridge, where he was admitted sizar on 17 May 1692, at the age of seventeen.
He was lecturer and curate of St Margaret's, King's Lynn, from 1711, and Rector of Bexwell (1708–9), Outwell (1709–18), and Watlington (1710–26).
Pyle preached in London, and his Paraphrase of the Acts and Epistles, in the Manner of Dr Clarke (1725) and another volume of paraphrases gained the support of dissenters and latitudinarians such as Samuel Chandler, Samuel Clarke, and Thomas Herring.
Pyle made no secret of his views on the Trinity, in which he adopted an Arian position, reveling in what he called "the glorious prerogative of private judgement, the birth-right of Protestants".
In 1732, he exchanged his old livings for the vicarage of St Margaret's, King's Lynn, which he retained until 1755, when he retired to Swaffham and died on 31 December 1756.