He is best known for his YouTube channel and Vine career, which lasted from April 2013 until the social media site was shut down by Twitter in 2017.

His work consists of comedy sketches, pranks, stories, singing and civil rights activism.

He reached over 7.4 billion loops and 8.3 million followers on Vine,[8] making his career one of the most successful in this social media platform's short history.

[28] His great-grandmother was a Ziegfeld Follies girl, something Sanders called his "ancestral connection with stage".

[36][Note 1] An impression of Stewie Griffin from Family Guy in a drive-thru was his first Vine to go viral, leading to continued success on the app.

[44] Sanders has collaborated with Viners such as Vincent Marcus,[45] Brandon Calvillo[46] and Amymarie Gaertner,[47] and featured cameos and appearances from figures such as Sean Bean,[48] Nicolle Wallace,[49] Stacy London,[50] Nick Pitera (with whom he did a series of Vines, Unexpected Duets),[51] Brizzy Voices,[51] Gabbie Hanna,[52] Tara Strong,[53] E. G. Daily,[54] Jim Cummings,[55] Dan and Phil,[56] Adam Pascal[57] and the main actors from Hamilton, Teen Titans Go!

[62] From the second half of 2016, at the same time his Vine activity slowed following Twitter's announcement of Vine's forthcoming closedown, Sanders announced he would be focusing on his YouTube content from then on in order to create more diversely formatted content.

The main channel would thereafter be dedicated exclusively to scripted series and shows as well as his music videoclips.

Sanders Sides consists of two seasons with a total of 33 episodes as of January 2024, released on a variable periodicity.

Tara Strong, who had already appeared in several Vines and Sanders Shorts, also made a voice cameo in Hartman's episode.

[69] On November 22, 2019, a companion series titled Sanders Asides was premiered, featuring the Sides in lighter stories in shorter episodes designed, in Sanders' words, to feature stories not directly linked to the main narrative.

Apart from his Internet-based career, Sanders has worked in musical theater at the Gainesville Community Playhouse[26] for productions including Hot Mikado (2007),[72] Singin' in the Rain (2009),[73][74] The Producers (2010),[75] Anything Goes (2011),[76] Into the Woods (2014),[33] and Les Misérables (2014).

[78] From August 8 to September 2, 2016, Sanders went on a stage musical tour, Ultimate Storytime, written by him with songs composed by Jacob Fjeldheim, and based on his Vine series Narrating People's Lives, performing in 17 cities in the US and Canada, including Toronto and New York City.

[20][21][22] In 2019, Sanders was cast as the understudy for The Beast in Beauty and the Beast[citation needed] In 2022, he joined Heathers The Musical in Concert, a benefit concert reunion of the 2015 Orlando cast of Heathers: The Musical, portraying again J.D., which earned him a nomination to Best Performer in a Musical in the 2022 BroadwayWorld Orlando Awards, as well as another nomination together with the rest of the cast to Best Ensemble Performance.

He has performed songs in a wide variety of genres but has personally showed a preference towards jazz music, mentioning Nat King Cole as one of his favorite singers.