Thomas Satterwhite Noble (May 29, 1835 – April 27, 1907) was an American painter as well as the first head of the McMicken School of Design in Cincinnati, Ohio.

Though Kentucky was a slave state not in the Confederacy, with the beginning of the Civil War, as a Southerner, Noble served in the Confederate army from 1862 to 1865.

With the success of his first painting, Last Sale of the Slaves, he received sponsorship from wealthy Northern benefactors for a studio in New York City.

After studying in Munich and towards the end of his life, Noble focused his artistic work on landscapes of Ohio and Kentucky countryside and Bensonhurst, New York.

His third painting, The Modern Medea (1867), portrayed the tragic event from 1856 in which Margaret Garner, a fugitive slave mother, murdered her children rather than see them returned to slavery.

Noble's last painting, Price of Blood (1868), was not based on a specific historical event, but depicted a white slave owner selling his mulatto son.