He was the oldest son of Richard Southwell, son of Sir Thomas Southwell, 1st Baronet, and his wife Lady Elizabeth O'Brien, daughter of Murrough O'Brien, 1st Earl of Inchiquin.
[3] In 1681, his father having predeceased him, Southwell succeeded his grandfather as baronet.
[4] During the Glorious Revolution of 1689, after he led an unsuccessful rising in County Galway, he and his brother were attainted by the parliament of King James II of England.
[5] In 1695, Southwell entered the Irish House of Commons for County Limerick, representing it until 1713.
[6] He was returned for the constituency again from 1715 until August 1717,[6] when he was elevated to the Peerage of Ireland as Baron Southwell, of Castle Mattress, in the County of Limerick.