[1] The elder Tyrwhitt-Drake was the son of William Drake, a long-standing MP for Amersham; the elder Thomas adopted the surname Tyrwhitt in 1776 in order to inherit the estates of his cousin Sir John de la Fountain Tyrwhitt, sixth Baronet, and then the additional surname of Drake in 1796 when his father died.
In 1805, Charles Drake Garrard resigned his seat in favour of the younger Tyrwhitt-Drake, who was duly returned for the borough in his place.
He voted against Catholic Relief in the early 1820s, and the Irish Franchise Bill in 1823, though he did deliver his constituency's petition for the Abolition of Slavery in 1824.
[21] Tyrwhitt-Drake took little part in politics at even a local level after 1832, though he did raise his objections over the repealing of the Corn Laws in the following decade.
He died 21 March 1852, leaving annuities to his wife and children, and passing his estates on to his eldest son, Thomas.