[1] In each episode Lamprey samples various food and drinks and learns about the customs and libations of that area, and then experiences the local hangover cure.

Typically over the course of the episode Zane will introduce different local alcoholic beverages and spend some time with either a bartender or alcohol-maker to learn more about the drinks discussed.

A voice-over feature starring "The Professor" will occasionally appear to introduce an in-depth history or description of something culturally significant, a locale, or the science behind a particular drink.

Zane also often refers to his drinking buddy, a stuffed monkey named Pleepleus, who appears at random points in the show.

[7] A small movement started in December 2009 with the philosophy to make the world a better place one drink at a time.

The essential rule for members of the movement is to purchase a drink for someone they don't know if he or she is seen wearing anything related to the show "Three Sheets".