Threlkeld is a village and civil parish in the north of the Lake District in Cumbria, England, to the east of Keswick.

It lies at the southern foot of Blencathra, one of the more prominent fells in the northern Lake District, and to the north of the River Glenderamackin.

[citation needed] Historically a part of Cumberland, Threlkeld formerly had its own railway station on the Cockermouth, Keswick and Penrith Railway, on the opposite side of the valley, next to the (closed) Threlkeld Quarry, at the foot of Clough Head.

Three rows of terraced houses, which used to accommodate the quarry workers, stand near the station.

From 1904 to 1958 High Row, Threlkeld was the site of the Blencathra Isolation Hospital, one of the first Sanatoria in England.