Thrombopoiesis

[2] The process of thrombopoiesis is caused by the breakdown of proplatelets (mature megakaryocyte membrane pseudopodial projections).

Apoptosis also plays a role in the final stages of thrombopoiesis by letting proplatelet processes to occur from the cytoskeleton of actin.

Platelets are also important in innate immunity and regulating tumor growth and vessel leakage.

[4] The megakaryoblast is a platelet precursor that undergoes endomitosis to form megakaryocytes that have 8 to 64 nuclei.

β1-tubulin microtubules, which are found in megakaryocytes, facilitate this process of shedding platelets into the bloodstream.