After graduating from high school, Quỳnh pursued her passion for the performing arts by enrolling in the Faculty of Acting at the University of Theatre and Cinema.

Thu Quỳnh began her acting career while still a student, appearing in TV series such as Nhà có nhiều cửa sổ and 13 nữ tù.

In 2019, Quỳnh further solidified her reputation through her role as Thu Huệ, the eldest sister, in the film Về nhà đi con.

The character, shaped by a tragic and challenging upbringing, navigates a life filled with inner turmoil and moral conflict, balancing between good and evil.

In 2022, Quỳnh appeared in the film Hành trình công lý, playing An Nguyệt, a diligent prosecutor and close friend of Phương (portrayed by Hồng Diễm).