In 1977 she was ordained as a Buddhist nun by Kyabje Ling Rinpoche in Dharamshala, and in 1986 she received bhikshuni (full) ordination in Taiwan.

Chodron has studied and practiced Buddhism in the Tibetan tradition extensively in India and Nepal under the guidance of the 14th Dalai Lama, Tsenzhab Serkong Rinpoche, Lama Thubten Yeshe, Thubten Zopa Rinpoche and other Tibetan masters and for three years at Dorje Pamo Monastery in France.

[1] Emphasizing the practical application of the Buddha's teachings in daily life, Chodron tries to explain them in ways easily understood and practised by Westerners.

She has worked on re-establishing the Bhikshuni lineage of Buddhist nuns, cultivating interfaith dialogue, and Dharma outreach in prisons.

Keen on interfaith dialogue, she was present during the Jewish delegation's visit to Dharamshala in 1990, which was the basis for Rodger Kamenetz’s The Jew in the Lotus, and she attended the Second Gethsemani Encounter in 2002.