The Tiburones competed in Fútbol Americano de México (FAM) for a single season in 2022, finishing with a league-worst 1–7 record, before the league folded in September 2022.

[4] They also signed former Borregos Salvajes Monterrey standout Máximo González, who participated in the National Football League (NFL) International Player Pathway Program, as well as former New Orleans Saints running back Khiry Robinson.

[6][7] A number of star players, such as David Casarrubias, Alejandro García and Humberto Noriega, decided to follow González's lead and leave the team over a perceived failure by the front office to deliver on promises made.

[8][9] Roberto "Gato" Silva was hired in March to replace Aparicio as the Tiburones' head coach,[10] but the 2021 FAM season was ultimately canceled due to the COVID-19 pandemic in Mexico.

[17] After a bye week, the Tiburones hosted the Tequileros de Jalisco in their home opener at the Estadio Andrés Quintana Roo and earned a 20–14 victory – the first in franchise history.

[23] Consequently, the Tiburones suffered the largest blowout in FAM history, losing 62–0 as more reports emerged of unpaid wages to players and coaching staff.

[24][25] Team owner Andrés Baños and sporting director Luis Tello continually refused to publicly address their troubles, drawing ire from local media.