The area of the uezd roughly corresponded to the contemporary Kvemo Kartli region of Georgia.

The Tiflis uezd as part of the Georgia Governorate was formed in 1801 as a result of the annexation of the Kingdom of Kartli-Kakhetian to the Russian Empire.

[1] Following the Russian Revolution, the Tiflis uezd was incorporated into the short-lived Democratic Republic of Georgia.

The plurality of the population indicated Georgian to be their mother tongue, with significant Armenian, Russian, and Tatar[b] speaking minorities.

1 January] 1916, including 283,326 men and 236,896 women, 339,668 of whom were the permanent population, and 181,554 were temporary residents:[7] This Georgia location article is a stub.