Tiger eye

[1] Horses displaying tiger eye typically have a yellow, orange, or amber iris.

SLC24A5 is found on equine chromosome 1 base pairs 141,657,837–141,678,329 and the protein is a potassium-dependent sodium–calcium ion exchanger involved in melanocyte maturation.

Tiger-eye 1 is a missense mutation (c.272A>T and p.Phe91Tyr) in which a single adenine is replaced with a thymine in exon 2, changing a phenylalanine to a tyrosine in the resulting protein.

Tiger-eye 2 is a deletion (c.875-340_1081+82del) in which the entirety of exon 7, and a bit of the introns on either side, are removed, resulting in a protein that is 69 amino acids shorter.

In humans a widespread mutation to the homologous gene plays a large role in the light skin color of European humans,[6] and another mutation can cause oculocutaneous albinism (OCA) type 6 (OCA6), which impairs vision.