[12] In December 2015, Keeper was cast in the role of Louise Mitchell in the BBC soap opera EastEnders,[13][14] appearing from 15 January 2016.

[15] Her storylines have included her father Phil's (Steve McFadden) alcoholism, being in a bus crash, getting caught in a fire causing her to have permanent burns, her mother's mental health issues, getting kidnapped, and becoming pregnant with Keanu Taylor's (Danny Walters) child.

In December 2019, it was announced that Keeper had made the decision to depart from EastEnders, with her final scenes airing on 24 January 2020.

[16][17][18] In April 2020, it was announced that Keeper would star in the BBC Three film Make Me Famous as Helen Cott.

[22] In June 2021, it was announced that Keeper would star as Emily in the British psychological thriller Marooned Awakening.