"[1] He is primarily known for his collaborations with writer Jeph Loeb, which included both comics work and artwork for the TV series Heroes.

Mr. Sale completed the "John Buscema Art School, which was advertised in the pages of Marvel Comics and held in a New York City hotel for a short time in the 1970s.

[12] At Marvel Comics, the team has produced the so-called "color" books such as Daredevil: Yellow,[13] Spider-Man: Blue,[14] and Hulk: Gray.

[17] Sale worked on artwork for the television program Heroes, where his frequent collaborator Jeph Loeb served as a writer and producer.

[18][19] In 2021, The Long Halloween was adapted for a two-part animated film from Warner Bros. Home Entertainment.

On June 13, 2022, Jim Lee announced Sale had been admitted to the hospital with severe health issues.

In an interview with the website World of Batman, Christian Bale, who played the character, characterized the "really fantastic imagery" with which Sale rendered those works.