[6] After graduating from SVA, Jimenez was hired by DC Comics Creative Director Neal Pozner at age 21,[4] with his first published work illustrating four pages in the 1991 miniseries War of the Gods.

[8][11] Jimenez has worked on several Teen Titans-related series (some issues of the ongoing series New Titans and Team Titans, and the miniseries JLA/Titans,[12] The Return of Donna Troy and Tempest),[7] was the main artist of Infinite Crisis, a sequel to Crisis on Infinite Earths, and did a long run as writer/artist of Wonder Woman beginning with issue #164 (Jan.

[7] Jimenez is also known for his work on various titles for DC Entertainment's "mature readers" imprint, Vertigo, including Swamp Thing, The Invisibles with writer Grant Morrison, and his own creator-owned series, the sci-fi/fantasy mashup Otherworld.

[17] Ana Kravinoff, the daughter of Kraven the Hunter, was introduced in The Amazing Spider-Man #565 (September 2008) by Jimenez and Marc Guggenheim.

[19][20] In 2009, Marvel Editor-in-Chief Joe Quesada announced that Jimenez would become the artist of Astonishing X-Men beginning with issue #31.

[7] He appeared at the White House for the National Design Awards to present original art to First Lady Michelle Obama.

[24] Jimenez appeared in a panel discussion on diversity in sci-fi/fantasy fandom in the March 19, 2015 episode of the Comedy Central humor and commentary program The Nightly Show with Larry Wilmore, along with Marvel Comics' director of content and character Sana Amanat, hip-hop artist Jean Grae and comedian Mike Lawrence.

[26] He got involved with Rebirth when he was originally assigned to be the artist of Superman but after DC changed their publishing plan, he was asked to work on Superwoman.

[29] Written by Kelly Sue DeConnick, the three-issue limited series takes place before the birth of Diana and tells of the creation of the Amazons and how Hippolyta became their queen.

The second Wonder Woman Historia: the Amazons issue was illustrated by Gene Ha and the third by Nicola Scott; an omnibus edition of the comics miniseries was released in June 2023.

[30] A diorama enthusiast, Jimenez teaches a life drawing course as part of the undergraduate cartooning program at the School of Visual Arts in Manhattan, where he himself once studied.

In scenes in which Peter Parker, played by Tobey Maguire, is seen creating sketches of his costume, the close-ups of his hands are actually those of Jimenez.