Timandra quickly began trading with the India and South East Asia under a license from the EIC.

EIC voyage (1820-1821): Captain John Price sailed from Falmouth on 19 July 1820, bound for Bengal.

Homeward bound, she passed Saugor on 3 April, reached Saint Helena on 19 July, and arrived at the Downs on 10 September.

[1] On her return Timandra's master changed from Price to E. Marshall, her owner from Dingwell to J. Benson, and her trade from Liverpool—Bengal to London—Baltic.

[4] Timandra sprang a leak in the Norwegian Sea 80 miles (130 km) off Lofoten, Norway, on 6 September 1822; despite their efforts the crew could not keep her afloat.