[2] The name "Tippah" is derived from a Chickasaw language word meaning "cut off."

It was taken from the creek of the same name that flows across much of the original county from northeast to southwest before emptying into the Tallahatchie River.

The creek probably was so named because it, and the ridges on either side, "cut off" the western part of the region from the eastern portion.

[4] As of the 2020 United States Census, there were 21,815 people, 7,834 households, and 5,394 families residing in the county.

24.90% of all households were made up of individuals, and 11.40% had someone living alone who was 65 years of age or older.