Tiszanagyfalu is a village in Szabolcs-Szatmár-Bereg county, in the Northern Great Plain region of eastern Hungary.

King Béla donated the uninhabited land, formerly belonging to the castle of Szabolcs, to Stephen of the Gutkeled family.

According to a charter dated 19 May 1364, in front of the Eger chapter, members of the Nogfalu family shared the parishionary church there, named after the Virgin Mary.

It was owned by Báthory in 1353, Baktay in 1420, Rohody in 1444, Farkas in Bogdány in 1451, Tuzséry in 1445 and Szabolcs Csűry in 1463 and the Lasztóczky family.

The former monastic land estate may have existed in the 15th century, at least in part of the village, because in 1465 it was mentioned as Újfalu, alio nomine Apáthszeg.

In the second half of the 16th century it was referred to as Nagfalu and Újfalu, but it was always the same place; the owners of Téthy and Csomaközy Boldizsár 13 and Rózsa Gáspár 7 serfs lived here.

It was held by the Csomaközy in the 17th century, but in 1683 it was donated to Captain Gergely Hatházi, a believer in Imre Thököly.

In the 1930s, the settlement is characterized by a strip-filled, originally one-street road village near the Tisza, in the open field.