Titanophoneus ("titanic murderer") is an extinct genus of carnivorous dinocephalian therapsid from the Middle Permian.

An adult skull would have reached 80 cm with a heavy long snout.

The long tail and short limbs show the species to be a primitive therapsid, unlike Inostrancevia, which was more advanced.

The structure of the limbs and the density of the bone are designed for a sprawling stance.

The appearance of Titanophoneus is reminiscent to the sphenacodontid pelycosaurs, which included Dimetrodon.