The Tittabawassee River (/ˈtɪtəbəˈwɑːsi/ TIH-tə-bə-WAH-see) flows in a generally southeasterly direction through the Lower Peninsula of the U.S. state of Michigan.

Its tributaries include the Chippewa, Pine, Molasses, Sugar, and Tobacco rivers.

Significant communities on or near the Tittabawassee River include Saginaw, Midland, and Sanford.

[8][9] Two emergency shelters had to be relocated due to flooding and electrical power losses.

Floodwater entered the Dow Chemical plant, forcing its shutdown and mixing with its containment ponds, leading to concern over pollution.