Bramble played in the Premier League for over thirteen consecutive seasons from 2000 and 2013, representing Ipswich Town, Newcastle United, Wigan Athletic and Sunderland.

[7][8][9] Bramble joined Newcastle in July 2002 for £6 million following Ipswich's relegation from the Premier League, vowing at the time to make himself indispensable to then manager Sir Bobby Robson.

[10] At the end of the 2003–04 season, readers of the football e-mail newsletter The Fiver voted Bramble as the worst player of the year in the Premier League.

[12] On 10 August 2006, Bramble scored another vital goal for Newcastle in the UEFA Cup second qualifying round with a header against Latvian side FK Ventspils.

[25] In August 2017, having been without a club for four years, Bramble joined Stowmarket Town, of the Eastern Counties Football League, as a player-coach.

In November 2014, he said it was a "disgrace" to apply the "Rooney Rule" to English football for compulsory ethnic minority management candidate consideration.

On 28 September 2011, Bramble was temporarily suspended by Sunderland,[30] after having been arrested on allegations of sexual assault and possession of a Class A drug.