Around the 11th century, a people called the Amaquemecan (after whom the municipality of Amecameca is named), migrated to this area following their leader Xolotl to look for a better climate and more food to sustain themselves.

[citation needed] The Acolhuas, Tepanecas and Otomis were already established in this land so alliances were made.

The founding of modern Tlalnepantla was the result of a dispute between the towns of Tenayuca and Teocalhueyacan as to which should be the site of Franciscan monastery and religious center for the area.

During the presidency of Porfirio Díaz, Tlalnepantla began industrial development, and in the 1950s underwent a demographic explosion after being declared a city in 1948.

[3] On January 16, 1977, Tlalnepantla del Baz was the site of one of the worst railway disasters in Mexico's history when a bus driver attempted to cross a railroad ahead of an oncoming train.

Tlanepantla is served by the local pesero, the Mexibús system, an intercity bus network and the Tren Suburbano at Tlalnepantla and San Rafael stations.

[citation needed] The church and monastery of Corpus Christi was built by both Nahuas and Otomis of pink and gray stone.

The aqueduct that extends from Tlalnepantla to Villa de Guadalupe as well as the Caja del Agua are works that date from the colonial period.

The Centro Cultural Sor Juana Inés de la Cruz has a collection of 130 fotografías del Tlalnepantla from the end of the 19th century to 1960 as well as other historical objects.

[6] A small museum on the grounds holds artifacts, diagrams, and models of the site and the history that surrounds it.