Following his return from Eastern Europe in 1965, he worked as a medical doctor in central Sudan and Khartoum, and then joined politics as a SANU member under the leadership of late William Deng Nhial Mabuoch.
He was subsequently appointed by President Jaafar Nimeiri as the first South Sudanese Commissioner of Bahr elGhazal Region in 1971, and then held several cabinet posts in the HEC under both Abel Alier and Joseph Lagu.
Dr. Maduot is a principled human rights activist, secularist thinker, and strong opponent of the war, enslavement, and other disasters that the government has been escalating against the People of Sudan.
He operated a small Medical Clinic in one of the most impoverished suburbs of Khartoum in Elhaj Yousif, and devoted himself to fighting for human rights and an end to the war in the South of the country from which most of his patients came.
He was constantly harassed and interrogated but consistently refused to comply with the security team's unlawful procedure, which flagrantly violated international human rights law.