Jeffrey Todd Grantham (born September 13, 1966) is an American football coach who is the defensive coordinator for Oklahoma State.

His D-Line was one of the catalysts of the biggest turnaround in league history (3–13 to 13–3), ultimately helping the Colts defense compile 56 sacks in two years, which was a club record since moving to Indianapolis.

After Mora was relieved of his duties in Indianapolis, Grantham moved on to the newly formed Houston Texans, joining the staff of former Pittsburgh Steelers defensive coordinator and inaugural Carolina Panthers head coach Dom Capers.

Grantham was given much talent to work with from the start, as the Texans acquired Pro Bowl defensive end Gary Walker and nose tackle Seth Payne from the Jacksonville Jaguars in the expansion draft.

In 2002, his influence was evident on the line as starters Gary Walker, Seth Payne, and Jerry Deloach all posted career highs in tackles.

2003 was a testing year for the line, as Pro Bowler Gary Walker and Seth Payne played a combined six games due to injury.

Despite the low number of sacks (5.5), they put great pressure on opposing quarterbacks (76 recorded pressures) and helped anchor the defense that was equipped with playmakers such as 2004 1st round draft pick Dunta Robinson, former Ravens linebacker Jamie Sharper, and veteran defensive backs Aaron Glenn and Marcus Coleman.

Grantham's first year as coordinator of the Browns defense under head coach Romeo Crennel was an eclectic mix of good and bad.

When starting cornerback Gary Baxter went down with a knee injury that ended his career, Leigh Bodden emerged as a solid playmaker.

In 2012, despite falling to 32nd nationally in total defense, the unit was revered as one of the top in the country as the team finished the season 12–2, winning the Eastern Division of the SEC.

Jones was Grantham's star player and was once again a consensus All-American in 2012, finishing the regular season leading the nation in tackles for loss, and 3rd in sacks.

Ironically, Grantham's predecessor at Mississippi State, Peter Sirmon, was hired to be defensive coordinator at the University of Louisville.

[11] Following his decision, Grantham received a contract extension and pay raise which made him one of the highest paid assistant coaches in college football.