[2] In 1975, Fangio played the defensive position of safety at Dunmore High School, outside of Scranton, Pennsylvania.

[3] While he did not play college football, Fangio did take several coaching classes during his time as an undergraduate student at East Stroudsburg University.

He was the defensive coordinator from 1995 to 1998 under head coach Dom Capers and helped the franchise advance to the NFC Championship Game in just its second season.

[14] After the departure of outside linebackers coach Clint Hurtt in 2017, Fangio assumed that position in addition to his role as defensive coordinator.

[26] On September 9, 2019, Fangio lost his regular season head coaching debut against the Oakland Raiders by a score of 24-16.

[28] On September 21, 2020, Fangio was fined US$100,000 by the NFL for not properly wearing a face mask, as required for coaches during the COVID-19 pandemic, during a Week 2 game.

Accordingly, all four were placed in league-mandated quarantine and were deemed ineligible to play in the Week 12 game against the New Orleans Saints on November 29, 2020.

Undrafted wide receiver Kendall Hinton, who played quarterback at Wake Forest and was promoted from the practice squad, served as the emergency starter, with running back Royce Freeman as the backup.

[32] On December 2, 2020, Fangio announced that the team had fined all four of its quarterbacks for violating COVID-19 protocols and not wearing masks while in close contact of each other.

[38] Fangio signed a two-week long contract to help with the Eagles' preparation for Super Bowl LVII against the Kansas City Chiefs.

However, before Gannon officially left the Eagles to become the head coach of the Arizona Cardinals, Fangio accepted an offer to become the new defensive coordinator for the Miami Dolphins.

[44] Fangio's addition eventually led to the Eagles winning Super Bowl LIX, in which his defensive unit was widely credited in overwhelming the Kansas City Chiefs' offense, sacking quarterback Patrick Mahomes six times and forcing three turnovers.

[45][46][47] Fangio was nominated for National Football League Assistant Coach of the Year Award, but finished fourth in the voting.