It has produced numerous series, including Sally the Witch, GeGeGe no Kitarō, Mazinger Z, Galaxy Express 999, Cutie Honey, Dr. Slump, Dragon Ball, Saint Seiya, Sailor Moon, Slam Dunk, Digimon, One Piece, Toriko, World Trigger, The Transformers (between 1984 and 1990, including several Japanese exclusive productions), and the Pretty Cure series.

Hayao Miyazaki, Isao Takahata, Yasuji Mori, Leiji Matsumoto and Yōichi Kotabe have worked with the company.

Toei Animation produced anime versions of works from manga series by manga artists, including Go Nagai (Mazinger Z), Eiichiro Oda (One Piece), Shotaro Ishinomori (Cyborg 009), Mitsutoshi Shimabukuro (Toriko), Takehiko Inoue (Slam Dunk), Mitsuteru Yokoyama (Sally the Witch), Masami Kurumada (Saint Seiya), Akira Toriyama (Dragon Ball and Dr. Slump), Leiji Matsumoto (Galaxy Express 999), and Naoko Takeuchi (Sailor Moon).

In October 2021, Toei Animation announced that they had signed a strategic partnership with the South Korean entertainment conglomerate CJ ENM.

[9] On March 6, 2022, an incident occurred in which an unauthorized third party attempted to hack Toei Animation's network, which resulted in the company's online store and internal systems becoming temporarily suspended.

The company investigated the incident and stated that the hack would affect the broadcast schedules of several anime series, including One Piece.

[15][16] The following day, the Japanese public broadcaster NHK reported that the hack was caused by a targeted ransomware attack.