Kasali came on board the Tinubu administration in the second term in 2003 as Commissioner for Rural Development.
He resigned from the cabinet to contest the governorship ticket of the Action Congress (AC), which the incumbent governor won.
From his last assignment as the Director-General of the BRF (Babatunde Raji Fashola) Campaign Organisation, Kasali took charge of the Ministry of Special Duties as Commissioner.
He ran for governor of lagos state in 2007 and in 2015 under the party APC (All Progressive Congress) but lost in the primaries.
Kasali's foray into administration began when he was elected as the chairman of ibeju-lekki local government.