[4] He scripted several Jimmy Olsen and Lois Lane stories for the Superman Family title; the final issue of Starfire (Oct.–Nov.

DeFalco later wrote a Machine Man limited series in 1984, with art by Herb Trimpe and Barry Windsor-Smith.

[5] DeFalco was the chief designer and author for Dazzler,[6][7] and later became one of the writers for the Spider-Man comic book series while at the same time rising through the editorial ranks.

While writing Dazzler, he wrote a couple of issues of Marvel Team-Up, before taking over from Dennis O'Neil as editor of that title, as well as assuming editorial duties on Ghost Rider, What If...?

[9] DeFalco worked closely with toy manufacturer Hasbro in the early 1980s, heading the creative team that "produced the backstory and dossiers that served as the basis for the relaunch of the phenomenally successful G.I.

Concurrent with editing Jim Shooter's Secret Wars, DeFalco introduced Spider-Man's "black costume" in the pages of Amazing.

DeFalco and Frenz were both removed from The Amazing Spider-Man by then Spider-editor Jim Owsley, who stated that they had chronically failed to meet deadlines.

[18] During his tenure as editor-in-chief, DeFalco had continued to write as well, with noted runs on Thor where he created the New Warriors with artist Ron Frenz[19] and the spin-off Thunderstrike, as well as Fantastic Four with artist Paul Ryan, and comics for Marvel children's imprint Star Comics.

[23] which led to him writing the MC2 line launched in 1998 including the Spider-Girl ongoing series[24][25] which ran for 100 issues.

In early 2009, as the Spider-Girl series was drawing to a close, DeFalco said it might be some of his last work for Marvel as he was in danger of being typecast because of his long run with the characters.

For Titan Books he has compiled three volumes in their "Comic Creators On..." series of essays and thoughts on Marvel characters (Spider-Man, the Fantastic Four and the X-Men, between 2004 and 2006).

DeFalco has personally created and developed over three dozen characters that have all been licensed for television, toys, T-shirts, posters, trading cards and other merchandise, and has written Khan and The Phantom for Moonstone Books.

[24][28] In April 2010, Archie Comics announced DeFalco would be returning to his roots, to write a four-part storyline, "The Man from R.I.V.E.R.D.A.L.E.

[33] In December 2016, Archie Comics launched a new ongoing Reggie & Me series by DeFalco and artist Sandy Jarrell.

Project, a new comic book written by DeFalco with pencils by Ron Frenz and inks by Sal Buscema.