Dine had served as chief executive officer of the Jewish Community Federation of San Francisco, president of Radio Free Europe/Radio Liberty in Prague, and as Assistant Administrator for Europe and the New Independent States of Eurasia at USAID.
He was also a Senior Analyst for the United States Senate Special Committee on National Emergencies and Delegated Powers from 1973 through 1974.
He played a main role, for example, in lobbying different branches of the US government in early 1986 over a US arms deal with Saudi Arabia.
In April 2013, Dine was one of 100 prominent American Jews who sent a letter to Israeli Prime Minister Benjamin Netanyahu urging him to "work closely" with Secretary of State John Kerry "to devise pragmatic initiatives, consistent with Israel's security needs, which would represent Israel's readiness to make painful territorial sacrifices for the sake of peace.
"[3] Dine is a member of Prague Society for International Cooperation, a respected NGO whose main goals are networking and the development of a new generation of responsible, well-informed leaders and thinkers.