They received a Master of Fine Arts from the University of California Los Angeles in 2002 where they studied with John Baldessari, Mary Kelly, Paul McCarthy, Lari Pittman, Pipilotti Rist and Wolfgang Tillmans.

Their work has been included in exhibitions at Palais de Tokyo, Paris; Contemporary Art Biennial, Sélestat, France; Malmö Konstmuseum, Sweden and the Whitney Museum at Altria, New York.

Work resides in the public collections of Albright-Knox, FRAC Bourgogne, Stiftung Kunsthalle Bern, and The Frances Young Tang Museum and Art Gallery at Skidmore College.

Utilizing abstract compositional constructions and modest sculptural materials, such as concrete blocks, folding chairs, and cereal boxes, the works bear witness to the condition of the inevitable.

Anne Doran writes, Holmes's work is "redolent of institutional limbos and marginal lives, with shrill bottom notes of failure and fear.