[2] Some of his best-known roles include Jedi Master Yoda and Admiral Yularen in Star Wars: The Clone Wars feature film and TV series, The Chancellor in 9, Magneto in Wolverine and the X-Men and Marvel vs. Capcom 3: Fate of Two Worlds, Ultron in Next Avengers: Heroes of Tomorrow and The Avengers: Earth's Mightiest Heroes, Mr. Herriman in Foster's Home for Imaginary Friends, Lord Monkey Fist in Kim Possible, Professor Utonium and HIM in The Powerpuff Girls, Oxnard Montalvo in The Angry Beavers, and Darwin in The Wild Thornberrys.

[3] Kane was also a prominent video game voice actor, appearing in numerous titles - from bit parts, to major roles such as Gandalf, Professor X and lead characters in many Star Wars games like Star Wars: The Force Unleashed as Imperial Captain Ozzik Sturn, Lobot and Kento Marek (the father of Sam Witwer's Galen Marek) thanks to ILM's motion capture technology.

In the arena of non-animation voiceover work, Kane recorded commercials, film trailers and television promos.

[8] In November 2020, Kane suffered a stroke which left him with significant weakness on the right side of his body and damage to his speaking, writing, and reading abilities.

[9][10][11] In September 2021, his daughter Sam confirmed that, due to his stroke, he had decided to officially enter an early retirement from voice acting.