The show will then typically be a mix of surreal celebrity interviews and short sketches, candid camera footage, and non sequiturs, usually focused on André's absurd behavior in regular settings.

Ending performances are usually parodies of amateur acts common to public-access television, while other times they are real musicians playing their own songs with heavy twists, such as punk band Trash Talk playing while wearing volume-sensitive shock collars or a female opera singer performing while rapper Killer Mike serves as her hype man.

In one episode, comedian Rory Scovel had a cooking segment in which he increasingly got upset and destroyed his work station while rapper T-Pain sang "The Star-Spangled Banner" and fired a gun in the air.

Season 1 stylistically follows the series pilot which was shot without studio backing on a limited budget, using vintage Ikegami cameras and a darkly lit set built in an abandoned bodega.

[citation needed] Guest stars appear throughout the show, with a number of them being faked with impersonators or random people, including Jerry Seinfeld, Russell Brand, George Clooney, The Hulk, Beyonce, Arnold Schwarzenegger (portrayed by Bruce Vilanch on a mobility scooter), and Jay-Z.

From seasons 2 to 6, more actual celebrities appeared, including musicians (Tyler, the Creator, Pete Wentz, Devendra Banhart, Killer Mike, Wiz Khalifa, T-Pain, George Corpsegrinder Fisher, Demi Lovato, Chance the Rapper, Mr. Muthafuckin' eXquire, Flying Lotus, Open Mike Eagle, Dave Koz, Mac DeMarco, 311), actors (Ryan Phillipe, Krysten Ritter, Dolph Lundgren, Jack Black, Aubrey Peeples, Jack McBrayer, James Van Der Beek, Chris Jericho, Seth Rogen, Macaulay Culkin), or 1980s/1990s television stars (Sinbad, Tatyana Ali, Lorenzo Lamas, Jodie Sweetin), although other guests have appeared, including television personality Lauren Conrad, talk show host Jimmy Kimmel, animation veteran John Kricfalusi, and adult film actresses Asa Akira and Mia Khalifa.

The season 5 episode "Blannibal Quits" marked the final television appearance of the late actress Naya Rivera, who was pronounced dead from accidental drowning at the age of 33 on July 8, 2020.

[17] André described himself as being "flat broke" and "scraping by doing commercials and random stand-up," including performing as a caveman for Geico, when he produced the pilot for The Eric Andre Show,[18] known originally as Duh Air Ache On Dre Shoe.

Knowing that it would be too difficult to explain how to edit the "slop pile of footage", André took on the task himself, spending a year learning Final Cut.

[18] Filming of the first season of the show saw André receive a large amount of creative freedom, but The Eric Andre Show did receive notes from "Standards and Production" at Adult Swim, particularly regarding suicide, drug use and insulting specific deities: André commented that "I can curse out God, but I can't curse out Jesus".

Adult Swim had already flagged the sketch, writing to the show: "He can shit so hard that organs fall out of his anus, but he can’t make it look like he’s intentionally doing it".

[18] Another scene planned, but not shot, for season 1 involved André jumping out of a manhole on the street wearing a prison uniform and handcuffs, yelling "I'm free!

but André was concerned with "get[ting] shot" and when the show contacted the city, they were warned of "toxic gasses in the sewer that you need special Hazmat suits for.

"[17] Additionally, André was arrested and spent time in jail during production of season 1 when he attended a town hall meeting in a frat-boy getup and announced his plans to put "beer in the water fountains and cameras in the girls’ locker room".

According to André, several cast and crew members on Don't Trust the B---- in Apartment 23 were not even aware of the existence of Adult Swim when explaining to them The Eric Andre Show.

[27] The special featured appearances from Demi Lovato, Sebastian Bach, Kevin Sorbo, Omarosa Manigault Newman, and John Kricfalusi.

With season 2, The Eric Andre Show changed to an HD camera setup, a new set design, and a new announcer, whilst André began wearing a suit.

André said this was because the studio's airconditioning was too loud to run while filming, but that it had the added effect of making the guests feel uncomfortable, in line with the show's theme.

André explained that the ground "was solid concrete evidently", and that he landed on his tailbone, "in this way that had this domino ripple effect up my spine so my body was asymmetrical for the rest of the year.

According to guitarist Matt Harvey, The Eric Andre Show originally wanted Pig Destroyer to perform, but they were unavailable, "so since we were in California, we got the nod."

[32] Man on the street segments included dragging a leaking body bag through New York's Chinatown; the production hadn't wanted to spend $300 on a filming permit and were ultimately met by police and other first responders.

[35][36][37] André said in an interview that he put on 20 pounds, shaved all of his body hair (except for his eyebrows), and "sat in many tanning beds" in preparation, describing his look as "this weird uncanny valley version of myself" which contrasts with his fourth season appearance.

[41] On October 22, 2020, André confirmed in an interview that Hannibal Buress would leave the series during the season for personal reasons, and he would be replaced with Blannibal, who is played by James Hazley.

"[43] During filming of one episode's set destruction intro, André ended up suffering a concussion when a shelf John Cena had thrown him into proceeded to fall backwards, causing one of its metal bars to hit him in the back of the head.

[44] Andre initially planned to end the series after season five, but was motivated to come back after he "didn't make any money" on his film Bad Trip after it was sold to Netflix.

Since there are only two chairs on the set, Buress ends up giving away his seat when a guest appears, awkwardly standing next to them and attempting to unnerve them from the host's behavior.

This entire band was replaced at the start of season 4 with a group of elderly men, including Don Peake as the guitarist, Emilio Palame as the keyboardist, Harold Cannon as the singer, Oscar Rospide as the bassist, and Tony Katsaras as the drummer.

John Bueno, Jermaine Fowler, Roy Subida, Pat Regan, Vanessa Burns, Byron Bowers, and Buddy Daniels Friedman have all made recurring appearances as crew members throughout various seasons.

At the conclusion of the first season, Christopher R. Weingarten of SPIN described the show as "possibly the weirdest (and most engrossing) ten minutes on contemporary television."

Sociologist Alex Prong of The University of Western Ontario explains that "Eric Andre’s embrace of postmodern irony serves him and his audience well, revealing the absurdity of American politics through satire and mimicry...Eric Andre may practice nihilism in that absurdism makes great comedy, but it is a hopeful nihilism, still with an eye for the future.