[3] He made his Crewe debut on 4 October 2016, coming on as a second-half substitute in an EFL Trophy tie against Wolverhampton Wanderers U23s at Gresty Road.

[4] The diminutive midfielder made what was regarded as a "sparkling" league debut four days later,[5] coming on at half-time against Luton Town at Kenilworth Road on 8 October 2016.

[16] He eventually resumed league appearances, coming on as a second-half substitute and scoring Crewe's goal in a 2–1 defeat at Wycombe Wanderers on 23 October 2021.

[20] During his 10th appearance, on 17 September 2022 against Plymouth Argyle, Lowery suffered a hamstring injury which ruled him out of League action until March 2023.

[21] In the opening game of the 2023–2024 season on 5 August 2023, Lowery suffered a torn meniscus in his knee, requiring surgery and a lengthy recovery period,[22][23] eventually returning to the first team in January 2024.