Etcheverry won his maiden Challenger title in Perugia, Italy, defeating top seed Salvatore Caruso in the semifinal, for his maiden top 100 win, and Vitaliy Sachko in the final, rising to a new career-high ranking of World No.

A week later he made his third Challenger final in Cordenons, Italy for 2021, where he lost to compatriot Francisco Cerúndolo.

Etcheverry made his Grand Slam main draw debut at the 2022 Australian Open after defeating Kimmer Coppejans, Jason Kubler, and Flavio Cobolli in qualifications.

As a result, he made his Grand Slam debut as a direct entry at Roland Garros, Wimbledon and at the US Open.

At the 2023 Argentina Open, he reached his first ATP quarterfinal after defeating Hugo Dellien and Roberto Carballés Baena.

[10] Etcheverry made his Masters 1000 debut at Indian Wells as a direct entry where he lost to Andy Murray.

He reached his second final of the season at the U.S. Men's Clay Court Championships, having to play four matches in two days due to rain, defeating qualifier Yannick Hanfmann in straight sets in the semifinal.

He recorded his maiden win at the 2023 Wimbledon Championships defeating Bernabé Zapata Miralles after being two sets to love down in a 4 and 1/2 hours match over two days after play was suspended due to darkness.

At the 2023 Swiss Indoors he reached again the quarterfinals taking his revenge on eight seed Sebastian Korda and Andy Murray.