In virology, the tombusvirus internal replication element (IRE) is a segment of RNA located within the region coding for p92 polymerase.

This element is essential for viral replication; specifically, it is thought to be required at an early stage of replication, such as template recruitment and/or replicase complex assembly.

[1] Other non-coding RNA structures in Tombusvirus include the 3' UTR region IV[2] and 5' UTR.

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