His early assignments including the formation of seminarians, parish vicar, and religion teacher in the public schools.

[1] Caputo joined the diplomatic service of the Holy See on 25 March 1980 where he occupied various posts at the Apostolic Nunciatures in Rwanda (1980–1984), the Philippines (1984–1987), Venezuela (1987–1989), and at the Secretariat of State (1989–1993).

[3] Caputo was appointed Titular Archbishop of Otriculum and Apostolic Nuncio to Malta and Libya on 3 September 2007.

[3] He was ordained a bishop by Pope Benedict XVI (principal consecrator), and the Cardinals Tarcisio Bertone and Marian Jaworski, on 29 September 2007.

[6] Pope Francis approved his additional appointment to the office of Assessor of the Order of the Holy Sepulchre effective September 2019.