Tommie Wayne Sisk (born April 12, 1942) is a former right-handed Major League Baseball pitcher who played from 1962 to 1970 for the Pittsburgh Pirates, San Diego Padres and Chicago White Sox.

Originally signed as an amateur free agent by the Pirates in 1960, he quickly made his way to the big leagues.

After 11⁄3 innings pitched, three walks, two hits and three runs surrendered, he was out of the game, which was against the hapless 1962 New York Mets.

He improved during his first season (in which he was the seventh youngest player), however, posting a 4.08 ERA in five games, three of which he started.

In his third year in the big leagues, he really struggled — in 42 games, he posted a 6.16 ERA, allowing 91 hits in 611⁄3 innings of work.

He spun a two-hitter that year, on September 20 against the team he made his big league debut against, the New York Mets.

The only two hits he allowed were a second-inning single by John Stephenson and a ninth-inning triple by Johnny Lewis.

On March 28, 1969, Sisk was traded with Chris Cannizzaro to the Padres for Ron Davis and Bobby Klaus.

Fellow reliever Gary Ross went 3–12, while starters Clay Kirby and Joe Niekro went 7–20 and 8–17, respectively.