Sweeney grew up in Ramsey, New Jersey and attended Don Bosco Preparatory High School.
In his final season with the Eagles, Sweeney had 32 catches for 348 yards and three touchdowns and was named first-team All-ACC.
[9] Sweeney made his NFL debut in the on September 8, 2019, in the Bills season opener, catching two passes for 35 yards in a 17–16 win over the New York Jets.
[11] Sweeney was placed on the active/physically unable to perform list (PUP) by the Bills due to a foot injury on July 28, 2020.
[17] In April 2021, Bills general manager Brandon Beane announced that Sweeney should be ready for the 2021 season.