Elections were held on November 2, 2010, to determine Michigan's 15 members of the United States House of Representatives.

[18] Lonnie Lee Snyder had intended to run as a Tea Party candidate, but was found ineligible to do so in August 2010.

Jason Allen, a member of the state Senate; Patrick Donlon, a businessman; Don Hooper, the owner of a trucking business; and Tom Stillings, a steel industry sales representative, also sought the Republican nomination.

[23] Linda Goldthorpe, a lawyer, suspended her campaign in July 2010; however her name remained on the Republican primary ballot.

[24] Dennis Lennox, the Cheboygan County drain commissioner, ended his campaign for the Republican nomination in March 2010.

[36] Though Benishek won the Republican primary by a margin of only 15 votes, Allen, who placed second, chose not to seek a recount.

[45] Bill Cooper, a small business owner; Wayne Kuipers, a member of the Michigan Senate; Chris Larson, a member of the Ferrysburg city council; Field Reichardt, the president of the Organic Olive Oil Co., Jay Riemersma, a former American football player; and Ted Schendel, a retired police officer, also sought the Republican nomination.

[47] Jeff Wincel, the owner of a consulting firm, sought the Republican nomination but ended his campaign in April 2010.

[66] Bill Hardiman, a member of the Michigan Senate; Steve Heacock, a former Kent County commissioner; Louise "Ellie" Johnson, an attorney; and Bob Overbeek, a United States Air Force veteran, also sought the Republican nomination.

[84] In 2010, Camp's opponent in the general election was Democratic nominee Jerry M. Campbell, a former supervisor of Richfield Township, Roscommon County.

[96] Green Party nominee J. Matthew de Heus, an instructor at Delta College, also ran.

[101] In October 2010 John Fund of The Wall Street Journal named the race as one of "five districts that could deliver upset victories", citing the possibility that Michigan's straight-ticket voting system would result in Rick Snyder's successful gubernatorial campaign affecting the results of congressional races.

[106] In 2010, Upton's opponent in the general election was Democratic nominee Don Cooney, a Kalamazoo city commissioner and professor of social work.

[46] Davis, a former police officer, had intended to run as a Tea Party candidate in the general election but was removed from the ballot in August 2010.

Marvin Carlson, a businessman; and Iraq War veteran Brian Rooney also sought the Republican nomination.

[123] Mike Stahly also briefly ran in the Republican primary, but ended his campaign due to fundraising difficulties.

[147] Rogers's opponent in 2010 was Democratic nominee Lance Enderle, who ran Leslie's alternative education program.

[149] Enderle ran unopposed as a write-in candidate in the Democratic primary after health care analyst Kande Ngalamulume suspended his campaign after the withdrawal deadline.

[159] Green Party nominee Douglas Campbell, an engineer; and independent candidate Matthew Kuofie, a professor at institutions including the University of Michigan, also ran.

Libertarian Party nominee Adam Goodman, a district manager for Ovations Dining; and independent candidate Bob Gray, an educator and former member of the executive board of the Michigan Republican Party,[46] both of whose names appeared on the ballot, ended their campaigns prior to the election.

[23] Anna Janek, a beauty consultant; Richard Kuhn, a former circuit court judge; and Paul Welday, a businessman, also sought the Republican nomination.

[185] In 2010 McCotter's opponent in the general election was Democratic nominee Natalie Mosher, a nonprofit consultant.

[188] Andy Dillon, the speaker of the Michigan House of Representatives, said in March 2009 that he would not seek the Democratic nomination.

[193] McCotter ended his campaign in September 2011[194] and resigned as a U.S. Representative in June 2012 after failing to qualify for the primary ballot.

[197] The 12th district included Clinton, Roseville, Southfield, St. Clair Shores, Warren and part of Sterling Heights.

[198] In 2010 his opponent in the general election was Republican nominee Don Volaric, the owner of a health insurance agency.

In 2010 Hansen Clarke, a member of the Michigan Senate,[47] successfully challenged Kilpatrick in the Democratic primary.

[46] John W. Broad, the president of Crime Stoppers of Michigan; Vincent T. Brown, a community organizer with Clean Water Action; Stephen Hume, a boat yard operator; and Glenn Plummer, the founder and chair of the Christian Television Network, also sought the Democratic nomination.

[224] In 2010 his opponent in the general election was Republican nominee Don Ukrainec, an instructor in the Riverview Community School District.

"Jack" Lynch, a database systems project manager with the Eaton Corporation; and Majed A. Moughni, an attorney, also sought the Republican nomination.